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This was not an easy decision, and we understand the impact it will have on some members who are currently using GLP-1s for weight loss
doi: 10.4331/wjbc.v10.i1.7
In brief, serum proteins were alkylated with iodoacetamide, digested with trypsin and spiked with heavy isotope-labelled synthetic peptide analogues (PEPotec, Thermo Fisher Scientific, USA)
In summary, the quest for a monthly GLP-1 injection faces a balancing act: delivering a large dose steadily and safely, avoiding local and systemic side effects, preserving drug stability, and doing it all in a manufacturable, patient-friendly format
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